姓名：张昂克
学科：预防兽医学
系别：预防兽医系
电话/传真：
电子邮件：[email protected]
通讯地址：郑州市郑东新区龙子湖高校园区15号 丝袜av 龙子湖校区第一实验楼
 

张昂克，男，副教授，博士研究生导师。主要从事动物传染病（病毒）教学、科研及社会服务工作，先后主持国家自然科学基金面上项目、河南省杰出青年科学基金等国家和省部级科研项目10余项，参与河南省高等教育教学改革研究与实践项目等教改项目3项并获省教育厅教学成果一等奖。国家自然科学基金通讯评审专家。以第一或通讯作者发表论文13篇，获国家发明专利3项。获校级优秀本科论文指导教师2次；指导本科生获得河南省大学生“挑战杯”特等奖，被授予优秀指导教师等荣誉。获得全国博士后创新创业大赛银奖，被授予全国创新创业优秀博士后，被省人力资源与社会保障厅记功1次。获省教育厅优秀科技论文二等奖2项。

本科生：《动物学》、《动物检疫学》、《生物安全》等

研究生：《实验动物学专题》等

猪繁殖与呼吸综合征病毒（PRRSV）的免疫调控及致病机制；病毒-宿主相互作用分子机制；非洲猪瘟（ASF）新型疫苗开发及检测技术等。

2021.09-至今 丝袜av 兽医学博士后流动站，博士后

2014.09-2017.06 西北农林科技大学，丝袜av ，预防兽医系，博士

2011.09-2014.06西北农林科技大学，丝袜av ，预防兽医系，硕士

2007.09-2011.06 河南科技大学，动物科技学院，动植物检疫专业，学士

2023.01-至今 丝袜av ，丝袜av ，副教授

2017.09-2022.12 丝袜av ，丝袜av ，讲师

河南省高校科技创新人才

河南省杰出青年科学基金获得者

丝袜av 高层次青年拔尖人才

1. 国家自然科学基金面上项目：NSP2***在PRRSV致肺损伤中的作用机制研究，2024.01至2027.12，50万元，在研，主持

2. 河南省自然科学基金青年项目A类（河南省杰出青年科学基金）：PRRSV G-四链体作为分子支架诱导NSP2***增强病毒致病性机制，2026.01至2028.12，50万，在研，主持

3. 河南省高校科技创新人才项目：PRRSV基因组RNA诱导Nsp2***的机制研究，2026.01至2028.12，30万，在研，主持

4. 国家自然科学基金青年项目：LncRNA MEG3对PRRSV感染的调控作用及分子机制，2021.01至 2023.12，24万元，结项，主持

5. 河南省科技攻关项目：基于纳米抗体-HRP融合探针的检测ASFV血清抗体新型ELISA试剂盒开发及应用，2020.01-2022.07，10万元，已结项，主持

6. 河南省高等学校重点研发计划：基于VSV反向遗传系统的新型ASF疫苗候选株制备及免疫原性研究，2022.01-2023.12，指导立项，已结项，主持

7. 河南省科技攻关项目：基于PRRSV感染性克隆为载体的新型ASF候选疫苗研发及免疫学评价，2023.01-2024.12，10万元，已结项，主持

8. 河南省博士后科学基金：PRRSV NSP2***鉴定及其影响病毒致病性分子机制研究，2023.01-2024.12，10万元，在研，主持

9. 丝袜av 青年英才基金：LncRNA MEG3竞争性结合miRNA181激活Nrf2/HO-1通路抑制PRRSV复制的分子机制研究，2020.12-2025-12，50万元，已结项，主持

10. 丝袜av 科技创新基金：血红素加氧酶-1在猪伪狂犬病毒疫苗株感染中的作用及分子机制，2019.01-2021.12，10万元，已结项，主持

(1) Jiahui Ren, Qiming Pei, Haoxin Dong, Xuedan Wei, Liangliang Li, Hong Duan, Gaiping Zhang^*, Angke Zhang^*. Tripartite motif 25 inhibits protein aggregate degradation during PRRSV infection by suppressing p62-mediated autophagy, Journal of Virology, 2024, 98(11): e0143724

(2) Hong Duan, Xu Chen, Ziwei Zhang, Zhijie Zhang, Zhihan Li, Xinjie Wang, Jiakai Zhao, Yuchen Nan, Baoyuan Liu, Angke Zhang^*, Yani Sun^*, Qin Zhao^*. A nanobody inhibiting porcine reproductive and respiratory syndrome virus replication via blocking self-interaction of viral nucleocapsid protein, Journal of Virology, 2024, 98(1): e0131923

(3) Hong Duan, Yaci Zhang, Aijuan Shen, Jiahui Ren, Fengxia Zhang, Yunshuo Lu, Xuedan Wei, Chaoyu Yang, Jiexi Gong, Xin Wang, Yongkun Du, Qiming Pei^*, Angke Zhang^*. Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway, Veterinary Research, 2025, 56(1): 182

(4) Haoxin Dong, Qiming Pei, Jiahui Ren, Yaci Zhang, Xuedan Wei, Aijuan Shen, Yunshuo Lu, Ziheng Zhang, Yongkun Du, Guoqing Zhuang, Angke Zhang^*, Hong Duan^*. Cholesterol-dependent Nsp5-endosomes co-trafficking to lysosomes facilitates porcine reproductive and respiratory syndrome virus replication by activating autophagy, Veterinary Microbiology, 2025, 305: 110507

(5) Ren, Jiahui ^#, Hong, Duan^#, Dong, Haoxin, Wu, Shuya, Du, Yongkun, Zhang, Gaiping, Zhang, Angke^*; TAT Nanobody Exerts Antiviral Effect against PRRSV In Vitro by Targeting Viral Nucleocapsid Protein, International Journal of Molecular Science, 24(3): 1905

(6) Duan, Hong^#; Dong, Haoxin^#; Wu, Shuya; Ren, Jiahui; Zhang, Mingfang; Chen, Chuangwei; Du, Yongkun; Zhang, Gaiping; Zhang, Angke^*; Porcine reproductive and respiratory syndrome virus non-structural protein 4 cleaves guanylate-binding protein 1 via its cysteine proteinase activity to antagonize GBP1 antiviral effect, Veterinary Research, 2022, 53(1): 55

(7) Zhao, Huijun^#; Ren, Jiahui^#; Wu, Shuya; Guo, Haoran; Du, Yongkun; Wan, Bo; Ji, Pengchao; Wu, Yanan; Zhuang, Guoqing; Zhang, Angke^*; Zhang, Gaiping^*. HRP‑conjugated‑nanobody‑based cELISA for rapid and sensitive clinical detection of ASFV antibodies, Applied Microbiology and Biotechnology, 2022, 106(11): 4269-4285

(8) Zhang, Angke^#; Wu, Shuya^#; Duan, Xiaohong; Zhao, Huijun; Dong, Haoxin; Ren, Jiahui; Zhang, Mingfang; Li, Jiaji; Duan, Hong^*; Zhang, Gaiping^*; K205R specifc nanobody-horseradish peroxidase fusions as reagents of competitive ELISA to detect African swine fever virus serum antibodies, BMC Veterinary Research, 2022, 18: 321

(9) Zhang, Angke^#; Duan, Hong^#; Zhao, Huijun; Liao, Huancheng; Du, Yongkun; Li, Liangliang; Jiang, Dawei; Wan, Bo; Wu, Yanan; Ji, Pengchao; Zhou, En-Min^*; Zhang, Gaiping^*; Interferon induced transmembrane protein 3 is a virus associated protein which suppresses porcine reproductive and respiratory syndrome virus replication by blocking viral membrane fusion, Journal of Virology, 2020,94(24): e01350-20

(10) Zhang, Angke^#; Zhao, Lijuan^#; Li, Na; Duan, Hong; Liu, Hongliang; Pu, Fengxing; Zhang, Gaiping; Zhou, En-Min^*; Xiao, Shuqi^*; Carbon Monoxide Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by the Cyclic GMP/Protein Kinase G and NF-kappa B Signaling Pathway, Journal of Virology, 2017, 91(1): e01866-16

(11) Zhang, Angke^#; Duan, Hong^#; Li, Na; Zhao, Lijuan; Pu, Fengxing; Huang, Baicheng; Wu, Chunyan; Nan, Yuchen; Du, Taofeng; Mu, Yang; Zhao, Qin; Sun, Yani; Zhang, Gaiping; Hiscox, Julian A.; Zhou, En-Min^*; Xiao, Shuqi^*; Heme oxygenase-1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication, Free Radical Biology and Medicine, 2017, 102: 149-161

(12) Zhang, Angke; Wan, bo; Jiang, Dawei; Wu, Yanan; Ji, Pengchao; Du, Yongkun^*; Zhang, Gaiping^*; The Cytoprotective Enzyme Heme oxygenase-1 Suppresses Pseudorabies Virus Replication in vitro, Frontiers in Microbiology, 2020, 11: 9-18(1) Jiahui Ren, Qiming Pei, Haoxin Dong, Xuedan Wei, Liangliang Li, Hong Duan, Gaiping Zhang^*, Angke Zhang^*. Tripartite motif 25 inhibits protein aggregate degradation during PRRSV infection by suppressing p62-mediated autophagy, Journal of Virology, 2024, 98(11): e0143724

(2) Hong Duan, Xu Chen, Ziwei Zhang, Zhijie Zhang, Zhihan Li, Xinjie Wang, Jiakai Zhao, Yuchen Nan, Baoyuan Liu, Angke Zhang^*, Yani Sun^*, Qin Zhao^*. A nanobody inhibiting porcine reproductive and respiratory syndrome virus replication via blocking self-interaction of viral nucleocapsid protein, Journal of Virology, 2024, 98(1): e0131923

(3) Hong Duan, Yaci Zhang, Aijuan Shen, Jiahui Ren, Fengxia Zhang, Yunshuo Lu, Xuedan Wei, Chaoyu Yang, Jiexi Gong, Xin Wang, Yongkun Du, Qiming Pei^*, Angke Zhang^*. Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway, Veterinary Research, 2025, 56(1): 182

(4) Haoxin Dong, Qiming Pei, Jiahui Ren, Yaci Zhang, Xuedan Wei, Aijuan Shen, Yunshuo Lu, Ziheng Zhang, Yongkun Du, Guoqing Zhuang, Angke Zhang^*, Hong Duan^*. Cholesterol-dependent Nsp5-endosomes co-trafficking to lysosomes facilitates porcine reproductive and respiratory syndrome virus replication by activating autophagy, Veterinary Microbiology, 2025, 305: 110507

(5) Ren, Jiahui ^#, Hong, Duan^#, Dong, Haoxin, Wu, Shuya, Du, Yongkun, Zhang, Gaiping, Zhang, Angke^*; TAT Nanobody Exerts Antiviral Effect against PRRSV In Vitro by Targeting Viral Nucleocapsid Protein, International Journal of Molecular Science, 24(3): 1905

(6) Duan, Hong^#; Dong, Haoxin^#; Wu, Shuya; Ren, Jiahui; Zhang, Mingfang; Chen, Chuangwei; Du, Yongkun; Zhang, Gaiping; Zhang, Angke^*; Porcine reproductive and respiratory syndrome virus non-structural protein 4 cleaves guanylate-binding protein 1 via its cysteine proteinase activity to antagonize GBP1 antiviral effect, Veterinary Research, 2022, 53(1): 55

(7) Zhao, Huijun^#; Ren, Jiahui^#; Wu, Shuya; Guo, Haoran; Du, Yongkun; Wan, Bo; Ji, Pengchao; Wu, Yanan; Zhuang, Guoqing; Zhang, Angke^*; Zhang, Gaiping^*. HRP‑conjugated‑nanobody‑based cELISA for rapid and sensitive clinical detection of ASFV antibodies, Applied Microbiology and Biotechnology, 2022, 106(11): 4269-4285

(8) Zhang, Angke^#; Wu, Shuya^#; Duan, Xiaohong; Zhao, Huijun; Dong, Haoxin; Ren, Jiahui; Zhang, Mingfang; Li, Jiaji; Duan, Hong^*; Zhang, Gaiping^*; K205R specifc nanobody-horseradish peroxidase fusions as reagents of competitive ELISA to detect African swine fever virus serum antibodies, BMC Veterinary Research, 2022, 18: 321

(9) Zhang, Angke^#; Duan, Hong^#; Zhao, Huijun; Liao, Huancheng; Du, Yongkun; Li, Liangliang; Jiang, Dawei; Wan, Bo; Wu, Yanan; Ji, Pengchao; Zhou, En-Min^*; Zhang, Gaiping^*; Interferon induced transmembrane protein 3 is a virus associated protein which suppresses porcine reproductive and respiratory syndrome virus replication by blocking viral membrane fusion, Journal of Virology, 2020,94(24): e01350-20

(10) Zhang, Angke^#; Zhao, Lijuan^#; Li, Na; Duan, Hong; Liu, Hongliang; Pu, Fengxing; Zhang, Gaiping; Zhou, En-Min^*; Xiao, Shuqi^*; Carbon Monoxide Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by the Cyclic GMP/Protein Kinase G and NF-kappa B Signaling Pathway, Journal of Virology, 2017, 91(1): e01866-16

(11) Zhang, Angke^#; Duan, Hong^#; Li, Na; Zhao, Lijuan; Pu, Fengxing; Huang, Baicheng; Wu, Chunyan; Nan, Yuchen; Du, Taofeng; Mu, Yang; Zhao, Qin; Sun, Yani; Zhang, Gaiping; Hiscox, Julian A.; Zhou, En-Min^*; Xiao, Shuqi^*; Heme oxygenase-1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication, Free Radical Biology and Medicine, 2017, 102: 149-161

(12) Zhang, Angke; Wan, bo; Jiang, Dawei; Wu, Yanan; Ji, Pengchao; Du, Yongkun^*; Zhang, Gaiping^*; The Cytoprotective Enzyme Heme oxygenase-1 Suppresses Pseudorabies Virus Replication in vitro, Frontiers in Microbiology, 2020, 11: 9-18

1. 第一届全国博士后创新创业大赛，银奖，中华人民共和国人力资源与社会保障部

2. 全国创新创业优秀博士后，中华人民共和国人力资源与社会保障部

3. 第一届全国博士后创新创业大赛中做出重大贡献，给予记功，河南省人力资源与社会保障厅

4. 河南省教育厅优秀科技论文一等奖：Interferon-Induced Transmembrane Protein 3 Is a Virus Associated Protein Which Suppresses Porcine Reproductive and Respiratory Syndrome Virus Replication by Blocking Viral Membrane Fusion，第1名

1. 河南省大学生“挑战杯”竞赛优秀指导教师

2. 丝袜av 优秀本科毕业论文指导教师

3. 河南省农业大学大学生创新创业优秀指导教师

4. 丝袜av “挑战杯”竞赛优秀指导教师